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KMID : 0043319940170020071
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Archives of Pharmacal Research
1994 Volume.17 No. 2 p.71 ~ p.75
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Antimutagenic Effect of Plant Flavonoids in the Salmonella Assay System
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Choi Jae-Sue
Park Kun-Young
Moon Suk-Hee
Lee Sook-Hee
Young Han-Suk
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Abstract
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The antimutagenic effects of 27 kinds of plant flavonoids on the mutagenicity of aflatoxin and N-methyl-N’-nitro-N-nitrosoguanidine(MANG) in Salmonella typhimurium TA 100 were investigated. In the mixed applications of with the flavonoids in the presence of a mammalian metabolic activation system (S9 mix), chrysin, apigenin, luteolin and its glucoside, kaempferol, fisetin, morin, naringenin, hesperetin, persicogenin, (+)-catechin and (-)epicatechin showed the antimutagenic effect against with more than 70% inhibition rate. A little or no antimutagenicities except flavone against MNNG were observed. For the antimutagencity of the flavonoids on , the flavonoid structure that contains the free 5, 7-hydroxyl gorup seemed to be essential. However, saturation of the 2, 3-double bond of elimination of the 4-keto group did not affect the activity.
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KEYWORD
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Antimutagenicity, Flavonoid, Salmonella assay system
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